Research activities at RPIL fall into the category of radiation physics and instrumentation that span over many areas of medical and non-medical applications. These projects mainly fit into development of high-performance and advanced radiation detectors by rigorously studying and addressing fundamental limitations of current radiation detector systems. Currect research include fabrication of high-performance scintillation detectors using laser-induced optical barriers (LIOB) technique, light transport simulation in crystals, detector-, and system-level modeling of radiation detectors, and system integration and characterization. Developing high-performance cardiac SPECT system, novel brain and small animal PET systems, photon counting CT detector system, and multimodality intraoperative imaging system are the current active projects.